Volume5

To study the frequency of haemolytic disease of newborn due to abo maternal-fetal incompatibility

Background:  Hemolytic disease of newborn is characterized by the presence of IgG antibodies in maternal circulation, which causes hemolysis in the fetus by crossing the placenta and sensitizing red cells for destruction by macrophages in the fetal spleen with consequent hyperbilirubinemia.
Aim:  Present   study  was done to find out  Prevalence of  ABO HDN in our hospital .

Critical variable parameters affecting industrially relevant bottom-up techniques of nanocrystal formulation

The solubility dependent bioavailability problem has become a major hurdle in drug development processes. Drug nanocrystals have been widely accepted by the pharmaceutical industry to improve the bioavailability of poorly water-soluble drugs. Poorly water soluble drugs show many problems in formulating a dosage form. Micronization does not sufficiently to enhance bioavailability and so next step is  nanocrystalization i.e.

Genetic predisposition analysis by glutathione peroxidase in patients on diabetic peripheral neuropathy [dpn] medication

To evaluate response of drugs used in the treatment of Neuropathy in patients with different genetic variants of Glutathione peroxidase enzyme. The details of Antihypertensive, Oral Hypoglycemic and Lipid lowering agents used by the patients was acquired in order to correlate with severity of Neuropathy using Toronto Clinical Score System.

Glycyrrhiza glabra extract attenuates polymicrobial interactions and disrupts biofilm formation by cariogenic microbes – an in-vitro study

Objectives: Polymicrobial interactions among oral microflora accelerate biofilm mediated oro-dental infections. Phytocomponents are gaining pre eminence in dental therapeutics owing to their multi factorial activity. Glycyrrhiza glabra (GG) due to abundant phytochemicals shows excellent bioactivity. Current study aims to evaluate the anticariogenic activity of ethanolic extract of Glycyrrhiza glabra and to elucidate possible mechanisms of action.

Biliary peritonitis revealing acalculous gangrenous cholecystitis

Gangrenous acalculous cholecystitis (GAC) is an acute nonspecific inflammation of the gall bladder, occurring in the absence of any gallstone in the bile ducts and whose symptoms start abruptly, rapidly evolving requiring urgent therapeutic decisions. GAC was described for the first time in 1947 by Glenn. We report the case of a 74-year-old patient who had poorly followed diabetes and presents an abdominal pain with a clinical examination that found a generalized abdominal defense.

Desmoplastic small round cell tumour of the peritoneum (a case report) and literature review

The peritoneum is a serious lining of mesothelial cells with a rich vascular and lymphatic capillary network that covers the abdominal and pelvic walls and organs. Peritoneal neoplasm can originate de novo from the peritoneal tissues and defined then as primary peritoneal carcinomatosis (PPC), invade or metastasize into the peritoneum from adjacent or remote organs and will be known as secondary peritoneal carcinomatosis (SPC), No ethnic predisposition or other known risk factors have been identified as specific for the disease.

Chemomechanical caries removal with brix 3000® in primary molar tooth: a case report

Chemomechanical caries removal is a new paradigm in Pediatric Dentistry. This technique philosophizes removal of only infected dentin and promotes availability of affected dentin for remineralization, thus providing a minimally invasive, atraumaticconservative approach towards dental caries management. This case report describes Chemomechanical caries removal in a 7-year old, apprehensive boyusing papain based Brix 3000®.

In vitro anticancer activity of silver nanoparticle synthesised from leaves of murraya koenigii against cancer cell lines

Objective: The primary point of the investigation was to screen the silver nanoparticle synthesized from the methanol concentrate of Murraya koenigii for its invitro anticancer activity against MCF 2, PC3, A-549, HeLa and HepG2 Cell lines. Methods: Silver nanoparticles were prepared from methanol concentrate of Murraya koenigii and nanoparticlesynthesised was analysed by UV, SEM and TEM analysis. The impact of nanoparticles synthesized on MCF-2, PC3, A-549, HeLa and HepG2 disease cell lines were assessed by MTT colorimetric assay.

Association of anaemia with low serum lipid concentration: our experience from a tertiary care center of eastern india

Background & objectives: Elevation of serum lipid levels increases the risk of atherosclerosis and coronary artery disease (CAD). The burden of coronary artery disease (CAD) in India is increasing and addressing the risk factors for the same is the need of the hour to reduce its prevalence. Another equally important public health concern is the prevalence of anaemia. Hence, we planned to determine if there is any correlation between anaemia and abnormalities in lipid profile in adult population which ultimately predisposes to CAD.