Background & objectives: Elevation of serum lipid levels increases the risk of atherosclerosis and coronary artery disease (CAD). The burden of coronary artery disease (CAD) in India is increasing and addressing the risk factors for the same is the need of the hour to reduce its prevalence. Another equally important public health concern is the prevalence of anaemia. Hence, we planned to determine if there is any correlation between anaemia and abnormalities in lipid profile in adult population which ultimately predisposes to CAD. Materials and methods:309 cases with anaemia and above the age of 18 years were enrolled along with equal numbers of matched controls. All participants were evaluated on the basis of haemoglobin, MCV, ferritin and lipid profile. Results: The lipid profile in subjects with anaemia and iron deficiency anaemia were lower than the non-anaemic control. Interpretation and conclusion: Lower lipid profile levels in anaemic individuals suggested that they were less predisposed to develop CAD as compared to non-anaemic controls.