To evaluate response of drugs used in the treatment of Neuropathy in patients with different genetic variants of Glutathione peroxidase enzyme. The details of Antihypertensive, Oral Hypoglycemic and Lipid lowering agents used by the patients was acquired in order to correlate with severity of Neuropathy using Toronto Clinical Score System. An Observational study was performed to ascertain prevalence of Peripheral Neuropathy in Type 2 Diabetes mellitus patients visiting department of Neurology and General Medicine in Princess Esra Hospital using patients of Diabetes mellitus without Peripheral Neuropathy as controls. The Allele specific analysis of odds ratio revealed that T allele carrying subjects may have nearly 2-fold increased risk of developing Peripheral Neuropathy. It is fascinating to know that individuals with CC genotype are headed to be associated with reduced risk of Neuropathy. We found that no specific pattern of a particular Neuropathy drug being used could be shown as accompanying with specific Glutathione Peroxidase genotype (CC, CT, TT).
