Human epididymis protein 4 as a tumor marker in ovarian cancer
HE4, Human epididymis protein is a whey acidic domain containing protein. It has serine protease inhibitor activity and also provides immunity against microorganisms. HE4 has emerged as a potential biomarker for the diagnosis of epithelial ovarian cancer. Limited success has been achieved using CA125 (Cancer Antigen 125), which is the only biomarker used for ovarian cancer. CA125 shows low sensitivity and specificity in the diagnosis of early stage ovarian cancer (OC). HE4 has major advantage over CA125 as it helps to distinguish malignant masses from benign one.