Objective: Prostate cancer is one of the most prevalence cancers in male and common cancer in the world. There are two main methods for control the prostate cancer but orchiectomy is highly effective for decreasing level of testosterone but some patients refused this method and been replaced by different forms of medical castration, often referred to as androgen-deprivation therapy (ADT). Materials and Methods: This systematic review was conducted based on the PRISMA checklist. Articles were extracted with selected keywords from the PubMed, SID, Springer, Medlib and Since Direct databases without any language restrictions. 100 articles were identified and after removal of unrelated or repetitive articles, 54 articles were selected. Results: Researches are ongoing to find out the way or better strategies to eliminate the adverse effects. Early detection of prostate cancer deaths is possible. Now, with new information and new therapeutic patterns, a high percentage of patients with prostate cancer have been able to fully recover. Conclusions: Many treatment modalities are important in the treatment of prostate cancer, but what is important to us in this research work is to compare the recurrence of the disease between the two groups of orchiectomies and drug treated patients with PSA levels that appear PSA increases later in the orchiectomy group.
