Assessment of oxidative stress parameters in metabolic syndrome patients with and without hypothyroidism

T4 (Thyroxine) and T3 levels lower than normal, and TSH levels greater than normal level indicates hypothyroidism. In hypothyroidism, reactive oxygen species (ROS) cause an imbalance in an individual's antioxidant/oxidant status, resulting in oxidative stress. Antioxidants play a protective function in the pathophysiology of diabetes and cardiovascular disease in individuals at high risk, such as those with Metabolic Syndrome. It is crucial to know how antioxidant concentrations are affecting these diseases. In this study, oxidative stress parameters were measured in 100 patients with and without hypothyroidism; 50 patients (33 females and 17 males) had metabolic syndrome, while the other 50 patients had metabolic syndrome without hypothyroidism. Plasma concentrations of MDA (7.80±2.36 µmol/L), TAS (14.62±5.05 µmol/L), GPx (29.21±6.60 µmol/L) and Catalase (23.77±8.64IU/L) levels were significantly higher in metabolic syndrome patients with hypothyroidism when compared to without hypothyroidism. Levels of TC (297.28±34.40), HDL (35.4±4.58), LDL (260.48±36.92) were increased and TGL,VLDL level were not significant between the groups.
Malondialdehyde, a lipid peroxidation product, was found to be elevated in metabolic syndrome patients with hypothyroidism, while protein oxidation was absent.