Background: Poorly controlled blood glucose levels can lead to complications in type 2 diabetes mellitus. The risk of the complications increases with an increase in the duration of hyperglycemia. Acute phase reactants are the markers of inflammation. In our study, we assessed the correlation of the levels of the acute phase reactants – HS-CRP, IL6, Ferritin with an increase in the duration of diabetes mellitus. Result: Interpretation of the data suggests that a longer time duration of having diabetes mellitus is directly correlated with increase in inflammation around the kidney as clearly seen by the increasing values of the inflammatory markers taken into consideration in this study which are HR-CRP, IL-6 and Ferritin. Conclusion: can be postulated that this pro inflammatory state is responsible for progression of disease and deposition of inflammatory complexes within the kidney. In this study we have taken into consideration patients having diabetes mellitus for upto ten years along with proteinuria as group I and those having for more than 10 years as group II. Inflammatory markers in early type 2 diabetic nephropathy are elevated and are independently associated with urinary albumin excretion. Microalbuminuria not only progresses to macrovascular disease in terms so frank diabetic nephropathy but also is an independent marker for Ischemic heart disease. Thus, its correlation to inflammatory markers may help in early detection and therapy.
