Background: C-reactive protein (CRP) and albumin level (ALB) are acute phase reactants and are used in many studies as mortality prognosticators.
Objective: The aim of this study is to evaluate the prediction performance differences betweenCRP at admission (CRP1)and its ratio to ALB(CRP:ALB1), CRP 1 week after admission (CRP2) and its ratio to ALB (CRP:ALB2),and percentage changes of CRP to ALB ratio during first week of ICU admission (% ∆ CRP:ALB ratio) for prediction of early ICU mortality (≤14 days of admission), late ICU admission (>14 days of admission), and overall 28-ICU mortality in critically ill patients with septic shock who were taking norepinephrine.
Methods: This single-center retrospective study conducted in the department of adult Intensive Care Unit (ICU) by examining the medical records between April 2017 to Sep 2018. Allpatient’s variables were analyzed using independent samples T-test, χ 2 test, or Mann-Whitney U test.
Result: The mean overall age was 58.37±9.96 years, and 112 subjects (68.71%) were male. The early, late, and overall 28-day ICU mortality rate were 16 patients (9.82%), 48 patients (29.45%), and 64 patients (39.26%), respectively.The CRP2, CRP:ALB2, and %∆CRP:ALB were significantly higher in nonsurvivors than survivors. %∆CRP: ALB shows the highest performance for prediction of late (66.00%) and overall 28-day mortality (81.40%) in compared with other tested prognosticators.
Conclusion: %∆CRP:ALB is an effective, realistic, dynamic, reliable, and discriminative prognosticator with high performance, specificity, positive predictive value, and accuracy when compared with other relative tested prognosticators for prediction of late and 28-day but not early ICU mortality.
