The main goal of periodontal therapy is to restore lost supporting tissue and re-establish a healthy maintainable environment. Guided Bone Regeneration (GBR) is a reconstructive procedure of alveolar ridge using membranes. This procedure is indicated when there is no sufficient bone for implantation, or in the case of optimal implant installation for esthetic or functional needs guided bone regeneration treatments for implant are used before implant placement or performed simultaneously with implantation (combined approach). GBR techniques have been used for socket preservation and for vertical and horizontal ridge augmentation for deficient ridge due to traumatic extraction, accidental loss of teeth, at the time of implant placement due to bony defects like fenestration, dehiscence and also to treat peri-implantitis defects. Many bone substitutes are available like autogenous bone graft, allograft, alloplast, xenograft for bone regeneration.