Transfusion Transmitted Infections (TTIs) are one of the major concerns for the blood transfusion services, which are an integral part of the current medical field. This study is intended to estimate the prevalence of TTIs among all the blood donors. This is a retrospective observational study carried out in the blood bank of a tertiary care hospital from January 2014 to December 2018 based on the records maintained in the blood bank. Total of 4499 blood donors were included in the study with 67% of them being replacement donors and 98.6% being male donors. The overall TTI positivity rate was 1.02% with HBV accounting for 0.97% and syphilis accounting for 0.04% of the positive cases. There were no seroreactivity for HIV, HCV and malaria. TTIs were observed exclusively in Male donors with the common age group being 21-30 years of age and 91.3% of the TTI positive blood donors were replacement donors. Adoption of stringent donor selection criteria and implementation of Nucleic Acid Amplification based Tests (NAT) for screening will help in reducing the incidence of TTIs.
