Aims:
1. To estimate and compare levels of salivary Urea, Creatinine and pH in chronic renal failure patients and in healthy individuals.
2. To estimate and correlate levels of Blood Urea, Serum Creatinine respectively with Salivary Urea, Creatinine in patients with chronic renal failure.
3. To explore potential of salivary Urea, Creatinine and pH as a markers for monitoring of mineral balance in the chronic renal failure patients.
Methods and Material: The recruitment of participants to the study was done at the Department of Oral Medicine and Radiology. Collection of blood, saliva samples and the analysis of all the samples was carried out at the Hematology and Biochemistry Laboratory of the institution.
Thirty patients were selected and they were placed in ‘Group A’.
Thirty healthy individual who had no relevant medical history were selected and they constituted the control group that is ‘Group B’.
Total 60 individuals were become participants of the study.
Informed consent was taken from patients and ethical committee approval taken.
Results: There was a statistically significant difference between salivary urea, creatinine and ph levels in the chronic renal failure group and control group (p<0.00001).
There was a positive correlation between the Salivary and Blood Urea in Chronic renal failure group and is also statistically significant (p=0.0016).
There was a positive correlation between the Salivary and Serum Creatinine in Chronic renal failure group and is also statistically significant (p<0.05).
Conclusions: Based on the results of the present study and data available from other studies, we propose that salivary urea, creatinine, pH has a strong potential as a marker in diagnosis and monitoring of chronic renal failure patients.
