Objective: COVID-19 has emerged as the biggest challenge to the mankind. Pleural effusion is one of the common manifestations of COVID-19. We present cytological findings in two cases of pleural effusion and one case of pericardial effusion related to COVID-19. Design: A report of three cases. Results: Two cases of pleural effusion that presented 20 days after recovering from COVID-19 and one case of pericardial effusion during the course of illness. All these three cases showed cytological features such as reactive mesothelial cells which can mimic malignancy. However, lymphophagocytosis was seen in all three cases which helped us not to label these cases as malignant. Conclusion: These cytological findings can be a mimicker of malignancy in COVID-19 patients. Hence, detailed history and investigations are needed to confirm the diagnosis.
