Introduction: The objective is to determine the main risk factors for the development of amputations in people with DM2. Material and Methods: A case-control study was carried out with 134 cases (people with DM2, with amputation in the pelvic limb) and 134 controls (people with DM2, without amputation in the pelvic limb). The association of variables was analyzed by Odds Ratio and a multivariate analysis model with logistic regression. Results: The final logistic regression model with the independent variables of years of DM2, history of ulcers, PAD, increases in HbA1c and ND. The value of R2 of Nagelkerke indicates that the proposed model explains 65% of the variance of the dependent variable. The percentage of success of the affirmations in function of the prediction indicates that there is an 82% probability of success in the result of the dependent variable, when I know the independent variables of the model. Conclusions: The main risk factors for the development of amputations in people with DM2 are: the history of ulcers, PAD, ND and HbA1c, in that order of importance according to their degree of association with the appearance of amputations.
