Dengue is the arboviral infection most common and important on global public health, classically presents with fever, headaches, and skin morbilliform rashes. Neurological symptoms and complications are uncommon but can be diverse, like myelitis, encephalitis, seizures and Guillain-Barre syndrome (GBS). GBS is a post infectious polyradiculoneuropathy that frequently develops after an infection, including viral disease. This case report a boy, twelve years old, that started with paresthesia in lower limbs and loss of muscle strength, evolving to headaches, vomiting and worsening of strength limb muscle. He was admitted on a reference hospital and transferred to Intensive Care Unit were we made investigation considering acute meningoencephalitis or acute flaccid paralysis. The presence of dengue specific IgM antibody test in cerebrospinal fluid and blood is an evidence that GBS occurred after dengue. This patient was treated with human intravenous immunoglobulin and evolved with progressive improvement in muscle strength and general clinical condition.