Conventional studies with evidence regarding the teratogenic effects of valproate was established which demonstrated that valproic acid is more teratogenic than other antiepileptics. Prenatal exposure of valproic acid in the first trimester of pregnancy is associated with an increased risk of congenital abnormalities and autism spectrum disorder and childhood autism. Use of valproic acid should be avoided or should take minimum effective doses if women are intolerable to others antiepileptics. It is recommended that higher standards of prenatal counselling and prescribing pattern with regard of valproate use should be followed. Women should to understand the risk of valproate and the choice of effective contraceptive methods should be reassessed and folic acid supplementation should be initiated.
