Introduction: Gallbladder diseases is one of the common GIT disorder. Various studies have shown correlation between gall stone formation and serum lipid abnormality. Objective: The aim of this study is to evaluate the various histological patterns of cholecystectomy specimens and compare the gall stone formation with cholelithiasis patients with control. Methodology: The study was conducted in the Department of Pathology- Sree Balaji Medical College and Hospital, Chennai during the period of January 2018-December 2018.Patients of all age group and sexes who underwent cholecystectomy were selected. Results: The total number of cases of choelcystectomy were 79 and the No of male-54, No of female- 25 and the mean age group- 44 yrs (21-76 yrs). The predominant lesion noted was calculous cholecystitis- 69 (88%). Abnormal total cholesterol seen in 87.5%, abnormal HDL in 62.5%, abnormal LDL in 87.5% and abnormal TGL seen in 68.5%. Conclusion: The cholecystectomy specimens revealed mostly benign lesions. An increased serum lipid profiles was noted in association with many lesions.
