The relationship of the serum vitamin d levels with asthmatic severity responses in asthmatic children

Rationale: Vitamin D has been found to have anti-inflammatory and immune-modulating effects.
Objective: the purpose of this study was to determine the relationship between the serum Vitamin D levels and clinical asthmatic types
Material and Methods: We studied 74 asthmatic children, aged from 5 to 15, who were admitted to the Children´s Hospital (Santisima Trinidad) of Córdoba, Argentina. The group was divided into severe asthma (n: 51), moderate asthma (n: 5), mild asthma (n: 18), in agreement with GINA and compared with healthy children (n: 21), sex and age matched, control group. We measured serum vitamin D levels.
Results: The patients in severe asthma presented normal level in 24, insufficient: 21, and deficient: 6 cases; in moderate asthma: normal 2, insufficient 1 and deficient 2, in mild asthma: normal 9, insufficient 8, deficient 1 and in controls all presented normal level (p= 0.0169). The IgE levels were in severe asthma 508±58.41 kU/L, in moderate asthma 329±78.91kU/L, in mild 172.9± 33.4 kU/L, in control: 37.86±5.44 kU/L, p<0.0001. The blood eosinophil levels were in severe asthma: 425.8±49.9 x mm3, in moderate asthma: 414± 75.77 x mm3, in mild asthma: 228± 31.59 x mm3, in control group: 160±15.7 x mm3 (p=0.0016).
Conclusions: There was not a correlation between serum vitamin D levels and asthma control statuses in our asthmatic children groups. More studies are required to determine the role of vitamin D in asthma.