The relationship of the serum vitamin d levels with asthmatic severity responses in asthmatic children

Orellana Julio César, Varela Telma, Romero Boni Ana, Miño Ofelia, Pautasso Estela, Skrie Víctor Claudio, Rivolta Susana, Pogonza Ramón, Muiño Juan Carlos

Rationale: Vitamin D has been found to have anti-inflammatory and immune-modulating effects.
Objective: the purpose of this study was to determine the relationship between the serum Vitamin D levels and clinical asthmatic types
Material and Methods: We studied 74 asthmatic children, aged from 5 to 15, who were admitted to the Children´s Hospital (Santisima Trinidad) of Córdoba, Argentina. The group was divided into severe asthma (n: 51), moderate asthma (n: 5), mild asthma (n: 18), in agreement with GINA and compared with healthy children (n: 21), sex and age matched, control group. We measured serum vitamin D levels.
Results: The patients in severe asthma presented normal level in 24, insufficient: 21, and deficient: 6 cases; in moderate asthma: normal 2, insufficient 1 and deficient 2, in mild asthma: normal 9, insufficient 8, deficient 1 and in controls all presented normal level (p= 0.0169). The IgE levels were in severe asthma 508±58.41 kU/L, in moderate asthma 329±78.91kU/L, in mild 172.9± 33.4 kU/L, in control: 37.86±5.44 kU/L, p<0.0001. The blood eosinophil levels were in severe asthma: 425.8±49.9 x mm3, in moderate asthma: 414± 75.77 x mm3, in mild asthma: 228± 31.59 x mm3, in control group: 160±15.7 x mm3 (p=0.0016).
Conclusions: There was not a correlation between serum vitamin D levels and asthma control statuses in our asthmatic children groups. More studies are required to determine the role of vitamin D in asthma.

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DOI: 23956429.ijcmpr20180352
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