Psychosocial mood symptoms; a common presentation in thyroid dysfunction

Aims and objective: This research aims at investigating the mood related consequences of thyroid dysfunction that could hint an underlying psychosocial mood disorder. 
Methods: This cross sectional study was conducted in the Medical and Psychiatry OPD at Ruth K.M. Pfau Civil Hospital, Karachi duringOctober 2018 to May 2019. Individuals aged between 20 and 60 years, attending the outpatient department, with some nonspecific mood complain were included while those with diagnosed psychiatric or thyroid disorder were excluded. All patients were followed with the measurement of TSH, Hb, ALT, ALP and RBS.
Results: Among 100 participants who completed the questionnaire. Mean age of 20 ± 1.7 years Mood swings and thyroid level shown a statistically significant association (p=0.047). When asked for symptoms they felt, a significant association was established between dizziness (p=0.031) and weight change (p=0.054). Additionally, thyroid levels in different age groups when compared show a remarkable association. 
Conclusion:This study establishes a positive relation of thyroid dysfunction with mood disorder symptoms, hence the authors conclude that thyroid profile plays a pivotal role in the pathogenesis and management of patients with mood derangements (or an underlying psychosocial mood disorder), and is related to the overall prognosis of such patients. Much more definite work needs to be done in this domain in the future for further validation.