Introduction: Prostate gland specimens account for the significant percentage of diagnostically challenging cases in surgical pathology practice. Benign prostatic hyperplasia is an extremely common condition in men over the age of 50 yrs. In India prostate cancers constitute about 5% of all cancers in male. Aims and Objectives:1) To estimate the various histopathological pattern of prostatic lesion.2) To estimate the occurrence of benign prostatic hyperplasia, prostatitis, type of carcinoma. Materials and Methods: This is a retrospective study of two years conducted at Azeezia Medical College, Kollam during the period of September 2018 to September 2020 with a total of 135 cases of lesions of prostate. The received specimen were fixed in 10% neutral buffered formalin and routine paraffin processing followed by Hematoxylin and Eosin staining was done. Lesion classified as benign and malignant and histologic grading done using modified Gleason score. Observations and Results: Total cases in the study period is 135. Non neoplastic case is 125 (92.5%), and neoplastic cases are 10(7.4%). The maximum number of BPH cases were seen during the age group of 60-70 yrs (34%) and also the maximum number of adenocarcinoma (3.7%) were seen in the same age group. The maximum number of cases were received as TURP 93.3% and the rest 6.6% as Trucut Among the cases the majority of cases were of BPH 73.3%, followed by BPH with prostatitis 14.8%, Adenocarcinoma 7.4%, followed by BPH with basal cell hyperplasia and granulomatous prostatitis 2.2%. In the malignant cases the most common modified gleason score is 4+4. Conclusion: Histopathological diagnosis and grading plays an important role in the management of prostatic cancer. For satisfactory management of patient, a high degree of the awareness of the advances along with team approach has become imperative
