Background: In 2020, there were 2.3 million women diagnosed with breast cancer and 6.85 lack death globally. As of the end of 2020, There were 7.8 million women alive who were diagnosed with breast cancer in past 5 year thus early diagnosis is necessary for proper management and to prevent early death of the patients. Histopathology is still the gold standard for the diagnosis of breast cancers. Self breast examination, screening programs, mammography, FNAC, MRI and immunohistochemistry also play important role in early diagnosis and proper management of the disease. Objective: To study the histopathological spectrum of breast lesions on the basis of type, age, sex and site distribution. Method: This retrospective study was carried out in the department of pathology, Chhattisgarh Institute of Medical Sciences (CIMS), Bilaspur, (C.G.) during January 2016 to Dec 2021. Study included total of 187 cases, 1000 blocks and 1200 stained histopathology slides (HandE stained). All mastectomy specimens received for histopathological examination suspected for neoplastic and non-neoplastic lesions of the breast were included. Women with obvious malignant disease or post radiotherapy /chemotherapy were excluded from the study. Detailed parameters were collected from histopathological register, studied and analyzed. Result: Total 187 cases of breast lesions were studied. 160 patients presented with lump, 26 lump with nipple discharge and rest present with nipple discharge, in which 186 (99.46%) were female and 01 (0.54%) were male. Out of 187 cases 49 (26.21%) were found Malignant and 138 (73.79) were benign lesions, Right sided breast lesion were 95(51%) Left were 87(46%) and Bilateral lesions were found to be 05 (3%). Among benign breast lesions most common was fibroadenoma 83(60.14%) followed by Fibrocystic disease 32(23.18%) of the breast. Among Malignant breast lesions most common was infiltrating ductal carcinoma 30 (61.22%), followed by medullary carcinoma 9(18.37%).Conclusion: In our study we concluded that infiltrating ductal cell carcinoma was the most common malignant lesion of breast. Clinical diagnosis is not enough for determination of the nature of lesion. Histopathological evaluation is important tool for diagnosis of invasive breast cancers also noninvasive and early stage breast cancers.