Introduction: Peptic ulcer disease, a common disease encountered in surgical practice. Relationship between the peptic ulcer and H. pylori is well established, but not clear with its major complications viz gastro duodenal perforation and bleeding. Aim: To find out the prevalence of H. pylori in perforated peptic ulcer disease patients. Methodology: All patients with perforated peptic ulcer who undergone emergency laparotomy were studied. Biopsies were taken from perforation margin and sent for detecting for H. pylori. Results: The study population ranged from 13 to 80 years of age with sex ratio of 6:1. Among 50 patients studied (n=32)64% of patients were positive for H. pylori. Among the 32 patients positive for H. pylori, 53% had previous history of dyspepsia. Conclusion: Hence treating these patients with H. pylori eradication therapy post-operatively, we can reduce the recurrence, reperforation and ensure rapid healing of peptic ulcer.
