Evaluation of the thrombolytic activity of kadikkara chendhooram- invitro study

Thrombolysis, also known as thrombolytic therapy, is a treatment to dissolve dangerous clots in blood vessels, improve blood flow, and prevent damage to tissues and organs. Several in vitro models have been developed to study clot lytic activity of thrombolytic drugs, but all of these have certain limitations. There is need of an appropriate model to check the clot lytic efficacy of thrombolytic drugs. Thus, the present study, is aimed to investigate in vitro thrombolytic activity of Kadikkara Chendhooram (KC).
It is a meto - mineral formulation contains three ingredients which prepared as per mentioned in Siddha Literature of Siddha Vaiththiya Thiraddu Page Number 157. The Thrombolytic activity of trial drug was evaluated using Healthy Human Blood Samples.
Under this study, Test drug KC demonstrated moderate (P <0.001) clot lytic properties in different blood samples. The percent clot lytic activity was compared with water (positive control) and standard enzyme streptokinase (negative control). Then again, the mean percent clot lytic activity of Test drug KC was found 60.22%, which is significant compare with the positive and negative control. So, the present research proposes that, the Test drug KC has moderate thrombolytic activity. Thus, the formulation is a source of effective herbal drug.