The neurodegeneration disease is a senile dementia characterized by loss of memory, attention and cognitive functions. The oxidants- antioxidant plays important role by several mechanism and role which reduces β-amyloid toxic to neurons, thus have been interest in dementia. Serum levels of Malondialdehyde (indicator of Lipid peroxidation), Ascorbic acid, alpha-Tocopherol and Pyridoxal phosphate were measured using standard methods in 50 patients of dementia and 50 non-demented age and sex matched subjects. There was significant difference observed between healthy controls and Alzheimer dementia, decreased serum levels of Ascorbic acid, alpha-Tocopherol and Pyridoxal phosphate and increased levels of serum levels of malondialdehyde when compared with healthy controls (p < 0.001). Average of MDA, Ascorbic acid, Alpha-Tocopherol and Pyridoxal phosphate for healthy Control group were 2.51with SD ±0.21, 1.77 with SD ±0.20, 8.16 with SD±0.47 and 27.95 with SD±0.21. Average of MDA, Ascorbic acid, Alpha-Tocopherol and Pyridoxal phosphate for Alzheimer dementia were 4.14 with SD ±0.41, (p < 0.001), 0.79 with SD ±0.02, (p < 0.001), 6.03 with SD±0.47, (p < 0.001) and 18.36 with SD ±1.92 (p < 0.001). Thus, altered oxidative stress markers may play important role in neurodegenerative diseases like Senile dementia.
