The neurodegeneration disease is a senile dementia characterized by loss of memory, attention and cognitive functions. The Aromatic Amino Acids act as precursors of important neurotransmitters which have important role in attention, cognition and thus have been interest in dementia. Blood levels of Large Neutral Aromatic Amino acids (LNAA) such as Phenylalanine, Tyrosine and Tryptophan were measured using standard methods in 50 patients of dementia and 50 non-demented age and sex matched subjects. There was significant difference observed between healthy controls and Alzheimer dementia, decreased levels of Tryptophan, Phenylalanine and Tyrosine when compared with healthy controls (p < 0.001). Average of Phenylalanine, Tyrosine and Tryptophan for healthy Control group were 27.95 with SD. ±6.09,46.52 with SD ±6.99 & 31.9 with SD±4.23. Average of Phenylalanine, Tyrosine and Tryptophan for Alzheimer dementia were 18.28 with SD. ±2.89, (p < 0.001), 20.49 with SD ±3.92, (p < 0.001) & 25.10 with SD±9.05, (p < 0.001). The results suggest that due to decreased concentration of large neutral aromatic amino acids lead to decreased levels of dopamine neurotransmission and serotonergic system in Alzheimer dementia patients and supplementation of aromatic amino acids may improve neuronal functioning and dopaminergic serotonergic activity in Alzheimer dementia.
