A simple, sensitive and precise U.V spectroscopic method have been developed and validated for determination of Canagliflozin in bulk and pharmaceutical formulations as per ICH guidelines. Canagliflozin showed absorption maxima at 291nm and was linear for a range of 2-10μg/ml with correlation coefficient 0.9999with having line equation y=0.1933X+0.893. The validation of above proposed method was done by carrying out precision and accuracy studies. The analytical method showed good precision with relative standard deviation 0.022% which is less than 2. The percentage recovery at three different levels i.e. 80, 100%, 120% was found to be 98.75%, 99.89%, 100.18%respectively.Percentage assay of Canagliflozin tablets (SULISENT®) was found to be100.03%.The results of analysis were validated statistically and by recovery study. The proposed method can be applied for the routine analysis of Canagliflozin from tablet formulation.
