Group A Streptococcus (GAS) is responsible for 30% of acute pharyngitis in children1. An estimated 600 million cases occur annually in over 4 years of age and more than 90% of disease cases occur in developing countries2. The antimicrobial susceptibility of pathogenic strains has been related to clinical informations in the treatment of pharyngotonsillitis due to antimicrobial resistance. Photodynamic Therapy (PDT) is a regularised treatment for cancer and other diseases. In PDT, non-toxic substances, the photosensitizer (PS) are accumulate preferentially in abnormal cells and microorganisms and photoactivated by visible light at specific wavelengths and reactive and oxygen species toxic to bacteria are generated. PDT presents advantages such as mechanisms for targeting of PS to microorganisms and non developed of bacterial resistance to drug. In two cases were studied the clinical and microbiological characteristics of treatment of acute pharyngitis in children using curcumin gum.