Comparative evaluation of scaling and root planing with and without sub-antimicrobial dose doxycycline in the treatment of patients with chronic periodontitis

Background: Periodontal disorder is a complex interaction of microbial factors and a susceptible host. Bacterial biofilm was able to directly cause destruction of periodontal tissues but the greatest destruction of connective tissue and bone structures are because of immunoinflammatory response of the host. It involves increased numbers of inflammatory and tissue destructive molecules like prostaglandins, cytokines and matrix metalloproteinases (MMPs).
Aim: This study was aimed to assess the role of sub-antimicrobial dose of doxycycline (SDD) as an adjunct to scaling and root planing (SRP) in the treatment of chronic periodontitis.
Materials & method: A total of 40 subjects having chronic periodontitis, with pockets depths ranging from 3 to 6 mm were selected.
Results: Were evaluated on the basis of clinical parameters such as GI, PI, GBI, OHI-S, PPD and CAL, in both the groups recorded at baseline, 1, 3 & 6 months.
Conclusion: SRP alongwith SDD showed significant reduction in almost all periodontal parameters when compared with SRP alone.