Introduction: Maxillary and mandibular bone defects are quite common. Among the different procedures that can be used to regenerate such defects we can find guided bone regeneration (GBR). This technique mainly uses a barrier membrane that can be resorbable or non-absorbable. Clinical Case: A 58-year-old female patient comes to the hospital for implant rehabilitation. Upon observing the CBCT and seeing a radiolucency compatible with root cyst at the level of the 12th piece, we decided to extract this piece, perform cystectomy and wait three months to make a GBR with titanium mesh, resorbable membrane and xenograft. After 6 months the reentry is made, the titanium mesh is removed, and two implants are placed. After 4 months, the prosthetic rehabilitation is performed with metal-ceramiccrowns. Discussion: After reviewing the literature, we observed that the average vertical and horizontal gain for GBR was 5.9mm and 5.6, obtaining in the present case an approximate horizontal gain of 5mm. It was found that the most predictable material for bone regeneration was autologous bone and as an alternative to it, no work was found that fully used xenografts (Cerabone). Conclusions: I can affirm that the use of titanium mesh together with resorbable membrane and Cerabone, is a useful alternative to GBR procedures that use autologous bone.