A cancer diagnosis is a major event for the person diagnosed and also to his or her family and caregivers. Family caregivers of cancer patients face many challenges in managing illness. The burden impacts physical, emotional, spiritual, and social health. The objective of this study was to identify burden among caregivers patients with cancer. The present study consisted of 300 caregivers of persons diagnosed with cancer fulfilling inclusion and exclusion criteria attending inpatient and outpatient services of cancer specialty hospital in KIDWAI Bangalore, Karnataka were randomly selected. Burden Assessment schedule (Thara et al, 1998) was administered to understand the burden. The interviews and the instruments were administered by research experts. This study concluded that female caregivers, single caregivers, other religion caregivers, caregivers who belong to rural domicile, caregivers not heard about treatment of cancer and other treatment methods had experienced more burden.