Objective: To effect of aminoguanidine (AG) on rats with renal injury as a result of unilateral ureteral obstruction was aimed.
Methods: 58 Wistar albino rats were randomly divided into 5 groups; there was no obstruction while applying laparotomy on the sham group (G1). After laparotomy without applying obstruction, sham + AG group was treated with 100mg/kg aminoguanidine intraperitoneal for 14 days (G2). After performing laparotomy on obstruction group, left ureter was defined and incised with a suture (G3). After performing laparotomy on AG group, left ureter was sutured, after that it was intraperitoneal treated with 100mg/kg aminoguanidine for 14 days (G4). For the last group, after ureteral obstruction, physıological serum was given as dissolver (G5). 14 days later, after bilateral nephrectomy, the tissue and blood samples were collected.
Results: After forming unilateral ureteral obstruction, tubular changes, pelvicalyceal dilation and inflammation in the AG group decreased when compared to the other groups. In obstructive left kidney tissue MDA and OSI values was significantly lower in the group treated with AG (G4) compared to the group without (G3), while the GSH and TAS values were determined higher. In obstruction made groups (G3, G4 and G5), a significant difference was not detected between SOD, CAT, GPx and the TOS levels. TAS levels in G4 and G5 was higher than G3, but OSI was found lower.
Conclusion: According to these results, it was showed that AG as histopathological formed anti-inflammatory and antioxidant effect in the unilateral ureteral obstruction rat kidney tissue
