Context: Parthenium hysterophorus, a weed belonging to Asteraceae family posses many significant medicinal properties like anti-inflammatory, anticancer, antirheumatic, antidiabetic and many more. Plant has been found to be pharmacologically active in the process of wound healing activity too.
Aims: The study was planned to study the wound healing activity of Parthenium hysterophorus in Wistar Albino Rats.
Material and Methods: Experimental study was planned in healthy adult Wistar rats of either sex weighing 150- 250 gms in the laboratory. Incision wound model test was used to evaluate the wound healing activity of hydro-alcoholic extract of aerial parts of plant. The results were expressed as Mean ± Standard Deviation (SD). The differences between experimental groups were compared by one-way Analysis of Variance (ANOVA) followed by test.
Results: The results obtained are clearly indicating that plant extract in both strengths i.e. 5% and 10 % showed excellent wound healing activity as compared with standard drug Soframycin in terms of increase in tensile strength. Particularly with 10% strength test ointment exhibited almost equivalent increase in the tensile strength as comparable with standard. Overall, there was dose dependent increase in wound healing activity.
Conclusions: Parthenium hysterophorus extract showed significant wound healing activity in terms of increase in tensile strength in experimental analysis.
