Use of letrazole for ovulation inductionwith good success results: study done in a small private setup

Clomiphene citrate and letrazole are two commonly used drugs for ovulation induction. Clomiphene citrate binds to the estrogen receptor at hypothalamus, blocking negative feedback effect of estrogen leading to increase GnRH and gonadotropic release thus causing ovulation. Letrazole is an aromatase inhibitor. Aromatase inhibitor act by blocking the conversion of androgens to estrogens in the ovarian follicles, peripheral tissues, and in the brain. This result in, fall in circulating and local estrogens. Thus, negative feedback effect of estrogens to hypothalamic pituitary axis is blocked causing release of FSH and thus ovulation. We studied letrazole for ovulation induction in a small private setup and found success rate of 37.17%.