COVID-19 has been confirmed a public health emergency across countries globally. Following the increasing incidences of the COVID-19 pandemic, healthcare professionals and healthcare systems are challenged by the surge of COVID-19 patients seeking medical assistance. Hospitalization for COVID-19 patients is increasing, which is associated with the severity of the disease. Hospitalization is needed for viral clearance and good prognostic outcomes. Understanding the underlying factors of hospitalization among COVID-19 patients informs medical opportunities to recognize at-risk people and develop clinical strategies to reduce adverse events and reduce the healthcare burden. This article highlights that age and inflammatory responses, gender, and preexisting medical conditions are the underlying factors of hospitalization. It is well-described that these factors increase the severity of COVID-19 illnesses, which requires further hospitalization of the affected people to provide the needed care and reduce mortality. Thus, taking into consideration such factors is crucial towards taking appropriate measures to reduce hospitalization rates of COVID-19 patients that pose an economic burden to the health care system and the country at large.
