Various countries had a concern on the effect of cadmium towards human health. Many researches and regulations have been implemented to control expose of cadmium from the environment or man-made source. Cadmium is known to have various impacts on health, especially diabetes mellitus, hypertension and peripheral vascular disease. Not many studies on the effect of cadmium on non-communicable disease particularly diabetes mellitus. Nearly 3.5 million of Malaysian had DM that can contribute to high morbidity and mortality. This review focuses on effect of cadmium towards DM to increase awareness of the public as well as stakeholders. Contribution and active programme from all stakeholders are necessary in the prevention and control of cadmium toxicity.