This study intends to find out various etiological factors, outcome, clinical manifestations, immediate outcome and short term follow up of surviving neonates presented with thrombocytopenia in their neonatal period (<28days of life). In our study 186 neonates admitted in NICU of RMMCH, Chidambaram with thrombocytopenia were studied. The prevalence of thrombocytopenia in our study is 19.36%. The most common etiology in neonates with thrombocytopenia is septicemia (48.65%). The most common clinical manifestation being respiratory distress (50%) followed by hemorrhagic manifestations (13.4%). In our study mortality rate is high among neonates who has thrombocytopenia associated with congenital malformations (4.8%). Neuro-developmental outcome of thrombocytopenic neonates in our study depends on associated features rather than severity of thrombocytopenia.