Objective The risk of malignant transformation of potentially malignant disorders is well established. Present study was undertaken to assess the values of antioxidants like malondialdehyde, superoxide dismutase, vitamin A and vitamin E in patients with these disorders and to analyze whether timely intervention with exogenous antioxidants brings these values, if deranged, within the normal range.
Material and Methods Our study comprised of 40 patients equally divided in two groups Group I included healthy controls and Group II with potentially malignant disorders. Serum vitamin A, vitamin E, MDA and SOD levels were assessed for group I and compared with group II. Group II patients were later administered with antioxidant therapy for six weeks, twice daily and were marked as group III post antioxidant therapy patients and the serum levels were reassessed and compared.
Results In group I the mean vitamin A level was 3.07±0.27, vitamin E was 9.89±0.75, MDA level was 2.92±0.36, SOD level was 189.45±14.17. In group II mean vitamin A level was 0.89±0.21, vitamin E level was 7.63±0.39, MDA level was 10.13±0.75, SOD level was 115.65±19.60. In group III mean vitamin A level was 1.09±0.11, mean vitamin E level was 8.04±0.53, mean MDA level was9.96±1.12, mean SOD level was 123.43±22.15.
Conclusion There was a significant reduction in serum Vitamin A, E and SOD levels in patients with potentially malignant disorders and a significant increase was seen after the administration of exogenous antioxidants. There was significant increase in serum MDA levels in patients with these disorders and antioxidant supplementation decreased the levels.
