As it is well known that the integrity of connective tissues surrounding dental implants is influenced by a levels of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). The purpose of this review was to provide an overall assessment of TIMP-1, MMP-1 and -8 levels as well as collagenase activities during the wound healing process after implant placement and diagnostic role in peri-implantitis.(1,7)
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