Role of gabapentin in chelation associated status dystonicus in wilson’s disease

Manish Kumar and Lokesh Kumar Tiwari

Status dystonicus is a life threatening neurological emergency which occurs secondary to etiologies like cerebral palsy, neurodegenerative disorders etc. Status dystonicus after initiation of chelation therapy with penicillamine in cases of Wilson’s Disease is not unknown and is generally refractory to usual antidystonic medications. We report a case of 10 year old male with Wilson’s Disease who developed status dystonicus after initiation of Penicillamine and was subsequently managed with Gabapentin as antidystonic medication for acute status dystonicus as well as long term therapy. This case illustrates the hitherto under recognised role of gabapentin as rescue medication in penicillamine induced status dystonicus in cases of Wilson’s Disease not just in acute phase but as long term antidystonic medication as well. More scientific evidence is required to establish formal pediatric dosing and duration of therapy for gabapentin for this medication.

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