In epithelial and stromal tissue there are morphofunctional zones, in which a proliferation and differentiation of cells occur. The zone consists of two subunits with 12 cambial cells in each. Function of cambial cells comes down first of all to an expression of the sufficient amount of inactive Src-kinase in daughter cells, which is necessary for the processes of a cytoskeleton formation and a differentiation. The differentiation is absent when the cambial cells quantity falls to 6. A hypothalamus (the central morphofunctional zone) controls the number of cambial cells. Estrogens, influencing a brain, gradually reduce the amount of inactive Src-kinase in a hypothalamus, which leads to change in a regulation of many hormones and decrease in cambial cells quantity. Thus, the risk of a cancer development and metabolism violation occur with age. Within that, the reduced amount of inactive Src-kinase in a brain leads to shortening of the processes of neurons and deterioration in synoptic transfer, which promotes the development of neurodegenerative diseases. Besides a hypothalamus local factors can also reduce the inactive Src-kinase. Large action of ultraviolet, sharply reducing the amount of inactive Src-kinase in a peripheral morphofunctional zone, can cause the development of a melanoma.
