Introduction: Poor Quality of Life (QOL) among medical and health students is related to an unhealthy lifestyle, psychological distress, and even academic failure that could affect their care for patients in the future. Material and Methods: This cross-sectional study was conducted among King Faisal University (KFU) students, particularly health college students, to evaluate their QOL using the Arabic version of the WHOQOL-BREF instrument for data collection. Results: A total of 346 students were included with a mean age of (21.4 ± 1.88) years. The majority (71.1%) was highly satisfied with their chosen specialties, and more than half of them (61.6%) had high job expectations. Females had a low psychological health score (53.02 ± 18.98) than the males (57.83 ± 19.95). Students with low specialty satisfaction levels had low physical activity score (56.53 ± 20.85), psychological health score (40.09 ± 19.56), social relationships score (43.39 ± 23.08), environment score (45.47 ± 18.65), and the overall QOL (41.81 ± 23.92). Conclusion: We reported a high level of specialty satisfaction and job expectation among KFU students in Saudi Arabia. Female participants were found to have significantly lower psychological health scores. Students with low GPAs (1-1.9) reported the lowest physical activity and overall QOL scores. Healthy students had better psychological health, environment, and overall QOL score than non-healthy ones. Low satisfaction among students was associated with poor psychological health, social relationships, environment, and overall QOL.
