Gonorrhea is one of the oldest known human illnesses. Despite the highly effective antimicrobial therapy available, it remains as a common sexually transmitted disease. Complicating this situation, new multi-drug resistant strains are emerging, making it a re-emerging public health threat. Presently, cephalosporins are the drug of choice and cephalosporin resistant strains are getting reported increasingly worldwide. This was a hospital-based prospective study conducted over 2 years to study the drug resistance profile of Neisseria gonorrheae strains prevalent in our population. Eighteen clinical samples were obtained and Neisseria gonorrheae was isolated from 15 samples. All isolates were obtained from male patients (Mean-age:25.89(±3.16)years). Direct smear examination was positive in 17 cases (94.44%). Antimicrobial susceptibility was studied and two isolates showing decreased susceptibility to ceftriaxone were found. Unrestricted, inappropriate selection and overuse of antibiotics, suboptimal quality of antibiotics and inherent genetic mutations within the organism have contributed to the development of this pattern of resistance in N. gonorrheae. The resistance will render it untreatable, increasing the reproductive morbidities. Furthermore, it facilitates the transmission of HIV by increasing the risk five-fold. Only an effective surveillance of the resistance profile and appropriate management regulations can curb the rise of this re-emerging threat
