Probiotic with lysozyme in the complex treatment of premature infants with infectious and inflammatory diseases

Kushnareva Maria Vasilievna and Shcherbakova Eleonora Grigoryevna

Background: Disturbances in the composition of the microbiota of an intestine and intestinal dysfunctions at premature newborns with infectious-inflammatory diseases.

Methods: Probiotic preparation Bifilis, comprising bifidobacteria and lysozyme, was used in the complex treatment of 45 premature infants (gestational age at birth was from 28 to 37 weeks) with infectious and inflammatory diseases complicated by intestinal disorders on the background of antibiotic therapy. Bifilis was administered for 2 weeks at 2.5 doses 2 times a day to newborn infants and at 5 doses 2 times a day – to infants older than 1 month. Intestinal microflora of all children was studied before and after the treatment course with Bifilis, and 22 infants were tested on sIgA and lysozyme concentrations in coprofiltrates.

Results: All infants had severe intestinal microbiocenosis disturbances prior to probiotic therapy. After the treatment course, the improvement of the clinical state and intestinal microflora was found in all children; among them, 10 infants was diagnosed with normobiocenosis and 22 infants – with grade 1 dysbiosis; the rate of sIgA and lysozyme detection increased by 3 and 2 times, respectively, and their concentration increased by more than 6 times.

Conclusions: Bifilis is an effective tool for intestinal disorders treatment in premature infants, including babies with very low birth weight and with infectious and inflammatory diseases. The probiotic normalizes the intestinal microbiota and increases the concentration of lysozyme and sIgA in the intestine.

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