Piper betle is glorified as evergreen and perennial plant that God designed and have given the shape of his own heart. The heart shaped of Piper betle leaves are initiate in ancient Sanskrit texts, include Charaka, Sushruta Samhita and Astanga Hradayam. Piper betle L. has been use in Chinese, Indian traditional medicine for centuries. Betel vine (Piper betle L.) belongs to genus Piper of the family Piperaceae. Leaves of Piper betle possesseveral bioactivities and are used in traditional medicinal systems. Many research studies on Piper beetle has reported that it contains important chemical constituents and are acts to arouse action for its medicinal properties like anticancer, anti-allergic, anti-malaria, anti-filarial, antibacterial, antifungal study, insecticidal, antioxidant, anti-diabetic, gastro-protective, cyto-toxic, anti-platelet, wound healing activity, chlorophyllase activity, oral hygiene and anti-asthmatic effect. The present paper also focused on the chemical constitutents of piper and diseases of betel vine and their various symptoms.