PATHOPHYSIOLOGY AND BIOMARKERS OF PRE-ECLAMPSIA

Preeclampsia is a pregnancy specific syndrome, characterized by high blood pressure and proteinuria
after 20 weeks of gestation in previously normotensive women.
Preeclampsia accounts over 60,000 maternal deaths annually worldwide.
In the pathophysiology of preeclampsia is involved abnormal uterine vascular changes, placental
ischaemia, increased oxidative stress, release of antiangiogenic proteins into maternal plasma,
excessive maternal inflammatory, endothelial injury, generalized endothelial dysfunction, atherosis, ,
hipercoagulative state, multiorganic manifestation, genetic implication.
There were identified and studied maternal serum markers for detection of preeclampsia. Those
markers that prove to be the most effective in prediction of preeclampsia could enter in clinical
practice.