Background: The study was done to compare the efficacy of combination of propofol-ketamine and propofol-fentanyl in terms of sedation, haemodynamic variables and side effects. Methods: The study was done on 60patients of (age 18-35 years, weight 40-70 kilograms) ASA grade 1&2. These were randomly allocated in 2 groups of 30 each. They were undergoing Dilatation and Curettage procedures lasting up to 30 minutes. Group A received Inj. Ketamine 0.75 mg/kg body weight IV slowly over 2 minutes, after 5 minutes Inj. Propofol given at rate of 1ml/3 seconds till loss of consciousness. Group B received Inj. Fentanyl 2 mcg/kg body weight as slow IV injection, after 5 minutes Inj. Propofol given at rate of 1ml/3 seconds till loss of consciousness. Ramsay Sedation Score, hemodynamic variables were recorded intra-operatively and hemodynamic variables recorded post-operatively at regular intervals. Use of rescue analgesia and side effects was also assessed. The results were tabulated and analysed statistically. Conclusion: Propofol-ketamine compared to propofol-fentanylgives good sedation as higher Ramsay sedation score was achieved and is more efficacious and provides better peri-operative hemodynamic stability during anaesthesia and also produces good analgesia with less requirement of rescue drug in post-operative period with fewer peri-operative complications.
