Liver diseases profile among patients of metabolic syndrome in north east india

Background: In the new era of urbanization where world disease burden is rapidly shifting from communicable disease to non-communicable disease, metabolic syndrome (MS) being the prime feature of it, liver diseases related to metabolic syndrome are also in the rise. In western nations nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease[3, 5, 10] and India is also not far behind from this fate. This present study is designed to evaluate the burden of various liver diseases associated with Metabolic syndrome.
Methodology: Newly diagnosed MS patients are evaluated thoroughly for presence of any liver disease by means of history, clinical examination, and biochemical profile and ultrasonography abdomen findings and further analyzed in details for statistical co-relations.
Results: 60.2% of total study population had underlying liver disease & most of them belonged to older age group (60.8%). In this male dominated study sample (52.8%) a bit higher female preponderance observed (51.4%) in disease prevalence. NAFLD was the most commonly observed hepatic abnormality 34.1% followed by raised transaminases (16.3%) and lastly cirrhosis (NASH related) i.e. 9.8%. Almost all the components of MS were more in the disease group, however BMI, raised total cholesterol level, & lastly low HDL cholesterol level were having significant statistical co-relation with presence of liver disease (<0.05) among the study population
Conclusion: A very high prevalence of liver disease in patients of MS had been observed in this part of the country with NAFLD being the most common spectrum among them.