Background- The ‘Sira’ term is used collectively for blood vessels (Arteries, Veins, Capillaries, and Lymphatic) which denote the circulatory system. Some siras are not suitable for vein puncture. These siras are called Avedhya sira. A surgeon should not perform venesection on this siras which definitely can cause disability or death. The sites are available in classic texts but the exact location and anatomical description not yet described. Therefore, it requires great research work to get a clear concept. Aim & objectives- To correlate Avedhya siras mentioned by our mentors with modern anatomical structures and review in contemporary science. Materials and methodology- Ancient Ayurvedic classics were reviewed and compiled references for said subject were critically studied to comprehend the Avedhya siras in extremities. Observations & Results – Scattered references are available in Ayurvedic classics and Modern Anatomy (Surgical & Clinical) texts regarding Avedhya Sira. Preliminary knowledge of Avedhya siras is very important for Physicians as well as surgeon. The Avedhya siras stated in Ayurveda compendia can be correlated with blood vessels, vein in Modern Anatomy.
