Invasive Non-typhoidal Salmonellosis (iNTS) is increasingly recognized as an emerging cause of blood stream infections in developing countries. With its diverse clinical presentations and alarming case fatality rate (20%: ranging from 3% to 50%), iNTS necessitates timely diagnosis and intervention. We report a case of invasive non-typhoidal salmonella (iNTS) infection in a 19-year-old girl who was managed appropriately based on a timely diagnosis. Detailed investigations did not reveal any other predisposing factors or evidence of an underlying immunodeficiency. Follow-up showed complete resolution of symptoms with no long-term sequelae. Invasive non-typhoidal salmonellosis was reported previously in patients suffering from chronic illnesses and immunosuppressed conditions. But, the incidence of iNTS is increasingly reported in immunocompetent hosts from developing countries. The proper diagnosis and timely treatment is essential and understanding of the pathogenesis between these correlations will assist in the development of preventive strategies for this illness.