Beyond doubt, in most cases improperly managed dental infections can result in fatal complications. Dental infections can lead to fatal complications if not properly managed. Three cases of oro-facial infection leading to life-threatening complications are reported here. The importance of supportive treatment, vigorous antibiotic therapy and elimination of source of infection in combating these complications have been stressed upon. Administration of high dose intravenous antibiotics is recommended, with the initial choice of antibiotics modified in the light of subsequent bacteriological reports.